Abstract: The northwest China is located at the superimposed tectonic domain of the Tethyan belt and the Paleo-Asian Ocean. This superimposed tectonic setting and composite structure result in favorable metallogenic conditions of polymetallic ore deposits. In order to promote the prospecting breakthrough and strategic action, the China Geological Survey deployed a number of 1∶50 000, 1∶250 000 regional geological survey and basic geological studying projects in northwest China. These projects achieve a number of discoveries and progress which are helpful to understand the metallogenic conditions. Considerable scale subduction-accretionary wedges with favorable metallogenic conditions are recognized and confirmed, especially in the southern margin of Altai region, the South Tianshan Mountains and South Kunlun. These accretionary wedges are subzone of orogenic zone, which are the most favorable areas for porphyry copper deposits and fault-altered rock type gold polymetallic deposits. Further research on the structure, magmatic activity and spatial distribution of the accretion orogenic zone will provide strong technical support for prospecting breakthrough.