Abstract: In recent years, the market demand for geothermal resources has increased intensely, and resource exploration and development in the Zunyi-Jinsha area of Guizhou has meet great development opportunities. It is an important task of geothermal geology work to change the relatively low success rate of geothermal wells in Guizhou, of which the geophysical logging is an important measure. Uncertainty exists in the interpretation of logging data, and it is necessary to combine logging theory and practical experience to improve the accuracy of interpretation results. Based on the geothermal logging exploration example in the northern suburb of Zunyi, the authors in this paper have comprehensively analyzed the logging response characteristics of physical parameters on rocks, such as natural gamma, resistivity, spontaneous potential, and acoustic waves. The comprehensive geological interpretation of actual measured curve in the wells were conducted by the logging character method in typical marker stata, sequence logging feature method, fault logging interpretation feature method, aquifer logging interpretation feature method and well temperature mutation logging interpretation feature method and 4 steps, to determine the typical marker layers and divide stratigraphic sequence. Besides, the fault structure and aquifer were interpreted. This research would provide a geological basis for the geothermal drilling positioning, geothermal well design and well completion technology selection in this area.