Abstract: In this project, the stratabound type and skarn type copper, lead, zinc, silver polymetallic deposit was selected as the main exploration target. We revealed the regional metallogenic geological background; found 111 mineralization anomalies; submitted 3 mineral deposits, 8 metallogenic areas and 23 prospecting target areas; established the prospecting indicators and prospecting model basing on a set of exploration methods includes 1:50000 geological mapping survey, ground magnetic survey, stream sediment survey, and remote sensing geological interpretation. In addition, we have the following new discoveries: 1) we recognized the Nyainqentanglha group complex, serpentinized peridotite and greisen-skarn type copper-tungsten deposit, skarn type bismuth deposits and indium deposit in the study area; 2) we found the Laigu formation and Mali formation have important exploration significance in Nyainqentanglha region, and proposed the regional sedimentary-transform metallogenic model. All these progress and achievements provide fruitful basic materials for further geological survey, mineral exploration and development.