Abstract: The large scale of metallogenesis in northern Xinjiang is controlled by complicated tectonic evolution and magmatism evolution in Late Paleozoic. This paper focused on magmatic Cu-Ni deposits, porphyry Cu-Mo deposits, and volcanic magnetite deposits. Geological process of magma activity was studied by origin, evolution and mineralization characteristic of ore-bearing intrusions. On the basis of typical deposits analysis, metallogenic models of different deposit types were established, restricted factors in prospecting breakthrough were revealed, geological characteristics and mineralization features caused by activity of plate tectonics and mantle plume were proposed. Characteristics of petrology, geochronology, geochemistry, magmatism and mineralization of Tarim mantle plume were closely related with the typical deposits in northern Xinjiang, and these indicated the mineralization in northern Xinjiang was controlled by Tarim mantle plume and plate tectonics. It is inferred that constantly decreased continental subduction and strengthened mantle upwelling may be responsible for the metallogenesis in northern Xinjiang, and the melt mantle material upwelled and mixed crustal rocks along the margin of rigid Tarim craton.