Abstract: By describing the research extent of and major findings from the regional geochemical prospecting work in East Kunlun-Altun Mountain, the effectiveness of the key techniques used for the regional geochemical prospecting there is illustrated; the enrichment and zonation of 39 elements present in this area are also outlined. Through studies, the authors demonstrate that East Kunlun-Altun Mountain is rich in multiple elements including Pb, Zn, Fe, Cu, Au, Ag, W, Mo, Sn, Sb and Hg, etc; Qimantag of East Kunlun is a polymetallic geochemical zone mainly of Pb, Zn, Fe, Cu, W, Sn, Au, etc; the Arca Mountain area is the principal Hg and Sb geochemical zone in East Kunlun; the Altun Au-Cu metallogenic zone and the Apa-Mangya ultrabasic rock belt are both geochemical zones bearing important geological prospecting significances. All these findings are highly indicative and referential for subsequent geological prospecting efforts in this area and also provide basis for this area to become an important target for integrated exploration and resource replacement.