Abstract: In this paper, regional geological structures and geochemical anomalies in Longhua County of Hebei Province are introduced, the favorable ore-forming factors in regional geology are proposed, and the indicative function of regional geochemical anomalies for polymetallic prospecting are interpreted according to the source, enrichment and precipitation of ore-forming elements, and characteristics of the ore-transmitting and ore-depositing structures in the study area. By analyzing the metallogenic essential factors of typical deposits under similarity geological conditions in study area, the direction, mineral assemblage, deposit type, and criteria for gold-polymetallic prospecting are proposed.