Abstract: Weishui Anticline is close to the urban area of Liupanshui City, which has favorable geothermal geological conditions with the formation of low and middle temperature geothermal resources. So it is rich in potential geothermal resources. However, the geological structure conditions are complex. And we have not enough recognition on the corresponding structure, type, burial conditions and spatial distribution of geothermal resources, so the region in the development and utilization of geothermal resources has not yet made a substantive breakthrough. The study of Weishui Anticline geothermal occurrence regularity and target prediction, it is supported by the results of the preliminary exploration work. On the basis of the comprehensive analysis and arrangement of relevant exploration data and by analysis of Weishui Anticline geologic background, heating conditions, thermal reservoir structure, geothermal carrier and its migration and recharge, this paper clearly indicated that this area belongs to the low and middle temperature type controlled by buried depth condition. The heat source mainly comes from the natural temperature formation (i.e. geothermal gradient). The geothermal carrier is mainly based on the ground water, and the type of the thermal reservoir is mainly the type of the thermal reservoir. Combined with existing geothermal engineering construction, the key reasons that the project failed to achieve the expected effect were analysed. It reveals that the heat reservoir layers are the Upper Devonian Raoshuo Formation (D₃y) and Wangchengpo Formation (D₃w), and the Middle Devonian Dushan Formation(D₂d). According to the heat reservoir top boundary depth contour of Weishui Anticline, the authors carried out the target prediction. The theoretical conservative water temperature is 44.7-59.7 ℃, and the stable geothermal water inflow is not less than 500 m³/d, which provides a basis for the further exploration and development of geothermal resources.