Abstract: The fault structure and the Lower Cambrian Niutitang Formation are widely distributed in northern Guizhou of the upper Yangtze platform. The Niutitang Formation is a set of marine sedimentary and is mainly composed of shelf deposit, especially deep water shelf deposit which is favorable for the formation of shale gas. Information from well Suiye 1 in the Niutitang Formation revealed that the upper deposit was a good cap rock, and the advantageous potential shale mainly located in the lower, with high organic matter abundance, high maturity, a large number of micro-fissure, high gas-bearing properties and favorable preservation condition. According to the comprehensive analysis of the shale gas geological characteristics, we proposed that the Niutitang Formation was a good prospect for shale gas exploration.