Abstract: Xuzhou has a long history in iron ore mining, and it is an old mining base with mature industrial production condition and recoverable resources exhaustion. Predicting the iron ore resources and mineralization potential scientifically has great practical significance in the study area. The relative reasonable predicting factors are selected according to geological background of iron ore resources in Xuzhou area; the effective prediction units are determined by correlation degree calculation. Furthermore, the linear regression analytical method is applied to estimate the resources of the prediction units, and the results are commented reasonably.