Abstract: In this project, we selected lead and zinc as the main exploration target, and the working area located in concentration zones of lead-zinc deposits from Zhangwei to Wuzhishan. On the basis of synthetic study, using the integrated geological and geophysical methods, combining with drilling and tunneling projects, the Nayongzhi deposit of Wuzhishan area and the Shuidong deposit of Zhangwei area have been explored. The prospecting effect was quite good that we estimated 333+334 lead zinc metal resources 2,156,500 tons, in which 333 lead zinc resources 520,300 tons. On these bases, we established the prospecting model of lead-zinc deposits in Wuzhishan area, forecasted that the prospecting area distributed in Shayan, Lishuiyan, Narun and Yujiaba of Wuzhishan area, Yizekong of Zhangwei area, Damachang and Yantang of Guohua area; and proposed that these area were worth of further exploration. After the late stage exploration, 3 medium mines were constructed, and local residents’ income and local government’s financial revenue were increased. This project has economy and social significance to Wumengshan poverty area.