Abstract: The West Kunlun-Altyn region features extremely bad natural environment and particularly poor transportation. In recent years, however, some breakthroughs have made in the geological explorations of the region, but its metallogenic geological setting investigation was obviously lagging. In order to improve the research level of metallogenic geological setting of the West Kunlun-Altyn metallogenic belt, the China Geological Survey deployed some regional geological survey projects and comprehensive research projects. These projects have got lots of achievements and progress: the spatio-temporal framework of strata, intrusive rocks and structures in the metallogenic belt has been established; significant ore-bearing geological bodies and ore-controlling structures have been surveyed; and the effects of important tectonic events on the mineralization have been studied.