Abstract: Globally, the search for low-carbon and sustainable hydrogen supply is a critical issue for the development of hydrogen-based society and the green transition of energy. Natural hydrogen, with its unique advantages of being zero-carbon and low-cost, is regarded as an important future supply method for hydrogen energy. Consequently, the exploration and development of natural hydrogen have become a research hotspot in the energy sector. However, natural hydrogen has a unique formation and enrichment process, and there is still no consensus on its favorable distribution areas. On the other hand, although there are small-scale commercial development cases, large-scale utilization of natural hydrogen remains a future prospect. The direct energy significance of natural hydrogen is still challenging, including direct exploitation and utilization. The indirect energy significance of natural hydrogen is that it promotes hydrocarbon generation from organic matter when it enters sedimentary basins, especially organic-rich shales. This indirect energy significance of natural hydrogen is not only great importance for enhancing the hydrocarbon resource potential of petroliferous basins, but also the most practical way to realize its energy value at present. The small sedimentary basins near plate collision zones are the most favorable areas for future breakthroughs in natural hydrogen exploration and economic utilization based on previous research, due to their combined conditions for the formation and preservation of natural hydrogen. The potential of multi-stage stacked intrusive bodies with strong hydrogen generation capacity promoting hydrocarbon generation in source rocks was explored in this study, with the Es4 source rocks in Yangxin Sag of Jiyang Depression as an example. The calculations show that intrusive bodies covering an area of 165 km² in Yangxin Sag can influence approximately 36.40 km³ of source rocks, increasing the crude oil resource volume of Es4 source rocks by about 1 796.34×10⁴ tons, which is 8.55% higher than the originally assessed resource. This study could provide a new perspective for re-evaluating the resource potential of small sedimentary basins with multi-layered deep intrusive sheets, and is of great significance for re-evaluating blocks traditionally considered to have poor exploration prospects due to tectonic activity.