Abstract: Fengyang Jiangshan gold mine is the largest gold deposit in eastern Anhui Province. In recent years, multiple exploration projects have been implemented in its surrounding areas without any good prospecting results. Through the use of geophysical methods, such as gravity scanning, gravity magnetic profiling, and audio magnetotelluric depth sounding (AMT), the authors summarized the characteristics of regional gravity and magnetic fields and considered that there are hidden tectonic magmatic rocks in the study area. The AMT low resistance anomaly zone is believed to be corresponded well with the gold bearing interlayer fracture zone, after the analysis of the geophysical characteristics of known mineral deposits. Besides, Lutang fault is the main ore controlling structure in the area, on basis of the summary and analysis of the geological conditions and laws of mineralization. Through gravity inversion, it is believed that the top interface burial depth of hidden rock mass in the deep part is mostly around 1 100 m. The 3D mineralization prediction research in Jiangshan of Fengyang area was conducted by 3D mineralization quantitative prediction method system with 4 steps, and 5 prospecting target areas were identified, providing the basis for the exploration work in the future.