Abstract: The southestern Tibet is a plateau region with steep mountains. The complex topography and geomorphology would easily induce geological disasters and increase the difficulty of engineering construction. In order to analyze the landslide susceptibility in this area, the authors in this paper selected eight evaluation factors as quantitative indexes, including distance from road, distance from water system, elevation, slope, slope direction, engineering geological rock group, soil type, and surface cover. The weighted value was determined by analytic nierardty process, and weighted informativeness model and weighted certainty factor (CF) were obtained by ArcGIS. Finally, the receiver operate curve was adopted to verify the accuracy of the results. The research vesullts are as follows (1) The AUC value of the weighted CF model is higher than the AUC value of the weighted informative ness model, and the covered landslide points from the weighted CF model the than those from the weighted informative ness model. So, the weighted CF model is more reliable in assessment of landslide susceptibility in this area. (2) The susceptibility zone is divided into high, relatively nigh, medium-high, relatively low, and low susceptibility zones by weighted CF model. The high susceptibility zone is mainly distributed in Mutuo and Gongjue counties, and relatively high susceptibility zone is distributed in Karuo and Mangkang counties. The medium-high susceptibility zone is distributed in Qiangwuqi, Dinching, and Janda counties, and the relatively low and low susceptibility zones are distributed in Bayi and Lang counties. The delineation of landslide-prone areas could provide some decision-making basis for the engineering construction in the region.