Abstract: In the background of high levels of heavy metal elements in Eastern Yinan, the authors collected 50 maize seed and root soil samples to investigate the interaction and bioavailability of heavy metal elements and trace elements closely related to human health in the soil-maize system. The content and enrichment characteristics of heavy metal elements and trace elements in the samples were statistically analyzed, and the interrelationship among the elements in maize seed and the root soil was explored through content analysis. The distribution patterns of heavy metal elements in maize roots, stems, leaves, seeds, and root soil were summarized and the safety of maize seeds was evaluated, by analyzing the content of heavy metal elements in corn roots, stems, leaves, seeds, and the forms of heavy metal elements in root soil. The results show that a significant difference of element content exists between maize root soil and maize seeds, and the enrichment coefficients of elements in maize seeds show significant- extremely significant positive correlation. As, Ni, Se in maize seeds have an antagonistic effect on the element content in the soil, while there is a synergistic effect among the elements in maize seeds. Cu, Zn, Cd, and Hg are mainly enriched in leaves, while heavy metals Cr, Pb, Ni, and As are mainly enriched in roots. All the samples meet the relevant standards of green and pollution-free except one maize seed sample, indicating the good safety level of maize seeds in the study area. This study could provide geological support for high-quality agricultural development and comprehensive soil pollution control.