Abstract: Tianming gold deposit in Anhua County of Hunan Province is located in the middle part of Xuefeng arc structure belt of Jiangnan orogenic belt, and the metallogenic geological conditions of the gold deposit are superior. On the basis of the comprehensive study of regional data and exploration results and combined with the geological data such as geophysics, geochemistry, and remote sensing, the authors compared and analyzed the metallogenic geological environment, orebody distribution, ore characteristics and genesis characteristics of Tianming gold deposit its adjacent typical gold deposits. The metallogenic geological conditions and prospecting criteria in Tianming area were discussed to preliminarily establish the metallogenic model and comprehensive prospecting model of the deposit. Three nearly EW-trending broken alteration zones in Tianming gold deposit were exposed. The genetic types of this deposit are orogenic-remelting magmatic hydrothermal type, showing the zoning characteristics of quartz vein type and structural altered rock type in the vertical zoning. The research results could provide reference for the exploration of Tianming gold deposit and similar types of gold deposits.