Abstract: In order to fully support and serve the new round of domestic mineral prospecting action for strategic minerals, the authors in “national gold key investigation area investigation and evaluation” program focus on the construction of large-scale gold resource base around the Gannan-Longnan, and conducted investigation and evaluation work of quartz vein type and tectonic alteration type gold minerals in Gansu Liziyuan-Huayagou key investigation area. The gold prospecting potential in Jiuzhanggou-Baguamiao section is still large, and 1 mineralized alteration zone and 4 mining sites (Yujiatang, West Huayagou, Madigou, Dashuigou) are discovered in central part of Huayagou-Dashuigou. The estimated potential gold resources of West Huayagou is verified to be 10.88 t by surface and drilling construction, with large-scale prospect. The next step includes strengthening the comprehensive study of the area, enlarging investigation level and carrying out deep verification in order to realize a breakthrough in mineral prospecting and safeguard nation energy security.