Abstract: As the important gold producing province in China, Liaoning Province has strong Mesozoic tectonic and magmatic activities, with great gold mineralization. Liaoning Province is divided into five key gold concentration areas, according to the spatial distribution characteristics of gold deposits. In order to deeply understand the diagenesis and mineralization of gold deposits in each gold concentration area, the authors systematically analyzed the geological characteristics, diagenesis and mineralization age, and the geochemistry of the gold concentration area. The results show that the gold mineralization in each gold concentration area is related to the magmatic activities of Indosinian and Yanshanian periods, and the metallogenic time is concentrated in 126~118 Ma and 225~188 Ma. The sulfur in gold ores in Western Liaoning gold concentration area belongs to mantle sulfur, while the sulfur in Eastern Liaoning gold concentration area comes from magmatic and metamorphic rock strata. The Pb in ore source of each ore concentration area has the characteristics of crust mantle mixed source. The source areas of the five key gold concentration areas are composed of the products of different magmatic evolution stages in the same magmatic source area. The ore material sources of five important gold concentration areas are magmatic evolution products from one magmatic source under different stages, and the diagenetic and diagenetic minerals are the products of partial melting of the lower crust, with the participation of some mantle derived materials. The geological model for gold prospecting prediction in Liaoning Province was established, combined with the recent prospecting progress, which could provide a new idea for further regional mineral exploration.