Abstract: The basic theory and exploration technology of helium resource in China have been lacking for a long time. In order to enhance the support capability of domestic helium resource, Xi'an Center of China Geological Survey took Weihe Basin as a base to carry out a continuous exploration on this unpopular field for over ten years. Geological research, geophysical exploration, geochemical surveying, helium survey of geothermal wells, gas logging, and modern testing technology were employed to pioneer the fundamental geological survey of helium. The geological conditions for helium enrichment have been successfully identified and prospective areas have been delineated in Weihe Basin. Furthermore, the reservoir formation theory of weakly sourced helium from crustal source was proposed and various accumulation models were established. Consequently, the essential requirements for helium-rich formation (with a minimum helium content of 0.1%) have been summarized, and the technical methods for investigating helium resource have been developed. This project has supported the identification of the domestic first mining claims for helium in Weihe Basin, and presented a pathway to secure helium resource, leading a “new round” of helium fever. The comprehensive summary of the progress made in the survey and research of commonweal helium resource was summarized, which could provide valuable insights for colleagues in the same field to carry out related research.