Abstract: As the newly discovered super large lead-zinc deposit in Northwestern Guizhou, the ore-controlling characteristics and prospecting potential of Zhugongtang lead-zinc deposit were analyzed through detail description of new discoveries in Zhugongtang lead-zinc deposit. The results show that the ore bodies of Zhugongtang lead-zinc deposit have a good extension in direction and tendency, and new ore bodies were discovered in Qixia Formation and Baizuo Formation of F₁ footwall, and Baizuo Formation of F₃ top wall. And 3 274 400 t lead-zinc metal resources were submitted, indicating a breakthrough in prospecting for lead-zinc deposits in Northwestern Guizhou Province. The mining area has important prospecting indicators such as structure, stratigraphy (lithology), wall rock alteration, magmatic activity, and geophysical and geochemical prospecting anomalies, and it also has good metallogenic geological conditions and potential to find more concealed lead-zinc ore bodies. This work can provide reference for the prospecting of lead-zinc ore accumulation in Northwestern Guizhou.