Abstract: The evolution of Lanping Basin in Yunnan during the Cretaceous period paved the way for the large-scale mineralization of Himalayan period. The analysis of the sedimentary facies of this period by the predecessors was relatively general, which affected the comprehensive understanding of basin evolution, nature and mineralization, to some extent. The authors in this paper carried out the survey of geological section and route in the middle of the basin, and concluded that Cretaceous in Lanping Basin is a combination of fan delta-lake and braided river delta-remaining river-lake system, which makes the basin a fault basin. Combined with the evolution of Tethys, it is believed that the basin continued to inherit a Middle-Late Jurassic subsidence tectonic setting in Early Cretaceous. The closure of Meso-Tethys Ocean at the end of Early Cretaceous interrupted the settlement of the basin. The northward subduction of Neo-Tethys Ocean terminated the sedimentary evolution of Mesozoic Lanping Basin. Based on regional mineral data, it is believed that the early Cretaceous mineralization elements have been initially enriched, and provided necessary mineral source layers, formation water, migration channels, and mineralization positioning space for Himalayan mineralization. This research can provide new empirical data for the evolution process of Lanping Basin.