Abstract: Dujiaqiao lead-zinc mine is located in Wumeng Mountain of Guizhou. On the basis of geological background and geophysical characteristics, the authors carried out Dual Frequency IP survey in this area. The equipment type and working method of IP middle ladder and symmetrical quadrupole sounding were introduced, and the geophysical anomalies were interpreted combined with geological characteristics and Laodong survey data. And the comprehensive application effect of these two methods was summarized and analyzed during the exploration of Dujiaqiao lead-zinc mine. The results show that the apparent anomalies are obvious in the IP middle ladder survey and symmetrical quadrupole sounding. So the authors deduce that the densely gradient variation of apparent resistivity is caused by the fracture structure, and the low-resistance and high-polarization anomalies are the favorable positions for lead-zinc mineralization, which has an important significance in ore search. The drilling verification indicates that the geophysical prospecting interpretation is in accordance with the drilling results, showing that Dual Prequency IP method is of geological efficiency in lead-zinc mine exploration in Wumeng Mountain.