Abstract: The Zhugongtang Pb-Zn deposit is located in eastern Sichuan-Yunnan-Guizhou lead-zinc polymetallic metallogenic region and northwestern Ziyun-Yadu fault zone. In recent years, new theories and methods have been successfully used to guide the prospecting and exploration, and this deposit has been discovered and basically identified as a super large lead-zinc deposit. According to the deep prospecting of Zhugongtang Pb-Zn deposit, this deposit was mainly controlled by NW Yadu-Mangdong fracture. And the ore host rocks were the limestone, marl, dolomite and dolomite limestone from Upper Devonian to Middle Permian. The ore bodies occurred with the shape of lenticular, veins and layers in the fractured zone, partially overlapped in the plan and parallelly staggered on the section. These ore bodies were hidden, steeply and deeply buried, with relatively concentrated ore-rich section and abundant useful components. The fault structure, ore lithology, wall rock alteration, and physicochemical exploration anomaly can be used as prospecting criteria. Through the study of the geological characters, ore-controlling factors and prospecting criteria of Zhugongtang Pb-Zn deposit, the authors thought that this area has huge potential economic value, and has important guiding significance for the regional Pb-Zn deposit prospecting, and Pb-Zn resource base and deep processing base establishment. It also points out the direction for the Pb-Zn prospecting in northwestern Guizhou Province. The discovery of this deposit has a profound impact on the poverty alleviation in the contiguous poverty-stricken areas of Wumeng Mountain.