Abstract: Nachitai area is located in the middle part of East Kunlun metallogenic belt. In order to solve basic geology and mineral resources problems in this important metallogenic belt, 1:50 000 basic geological and mineral survey was conducted. The results show that strong strain zone and mylonitization zone are frequently alternate in the research area. The schistositized and mylonitized structures are common in the brittle-ductile shear zone, such as S-C fabrics, rotational porphyroclast and asymmetric folds. EW and NWW trending structures developed.The newly identified structural traces, combined with some newly discovered gold, copper, lead and zinc deposits and mineralization clues, are consistent with the majority of ore deposits, ore spots, and the occurrence of EW-NWW-toward linear tectonic belts in the region. This indicated a direct or indirect relationship between the mineralization and the structures. A closed relationship is shown between the EW and NWW structures and polymetallic deposits in time-space and genesis. Kunlun River ductile shear zone was formed in Late-Middle Silurian (432-423 Ma), which is similar to the newly discovered Erdaogou scheelite and Tongjinshan tungsten-tin ore in this reaserch area. This research shows that the potential of regional prospecting is great in this area.