Abstract: In order to investigate the deep mineral prospecting potential of Qijiashan-Makou area in central and eastern Luzong ore-concentrated area, the authors extracted the deep gravity and magnetic fields with the wavelet transformation method, and emphasized the local anomalies of deep gravity and magnetic fields through parametric transformation of vertical first-order derivative Z and horizontal derivative modulus S. Combin with the results of spectrum induced polarization (SIP) and controlled source audio-frequency magneto tellurics (CSAMT), the authors found out a high gravity and low magnetic, low resistivity and high polarization anomaly belt in the deep of the research area, which is longer than 3.0 km and wider than 0.5 km. According to the distribution law of the known copper ore (mineralized) bodies inside and outside the research area, combin with the distribution of known ore (mineralized) bodies in the deep gravity and magnetic anomalies and the verification results of zk4601 drilling, the authors considered that the anomaly belt is the reflection of copper polymetallic mineralized alteration zone and a favorable part of copper polymetallic prospecting, which has a good prospecting perspective.