Abstract: In order to support the strategic action of prospecting breakthrough and serve reserve base construction of national mineral resources, under the new overall layout of China Geological Survey for 3-level project management systems, Xi'an Geological Survey Center carried out a geological and mineral survey in the main metallogenic belts of Northwest China together with more than 30 institutions including Institute of Mineral Resources(Chinese Academy of Geological Sciences), China Non-Ferrous Metals Resource Geological Survey, the Cores and Samples Center of Land and Resources, and Zhengzhou Institute of Mineral Resources Multipurpose Utilization. Based on the existing achievements, more than 200 mines and mineralized spots were discovered, and more than 70 prospecting target areas were delineated. In addition, batches of prospecting achievements are supported by local funds continually and some of them have been auctioned successfully in the last two years. These effectively attracted some social capital investment, promoted the prospecting breakthrough, deepened the understanding of metallogenic regularity of copper, nickel, gold, graphite and hard rock type uranium deposits, and also supported the construction of large mineral resource bases. We innovated some new technologies such as mapping in orogenic belts and Gobi desert areas, the integration of project achievements, and mapping technology, and realized the coordination between national funds and local capital investment. The platform construction of science and technology and talents cultivation was supported in the meanwhile, and the large project mechanism was realized. This paper focused on the geological and mineral survey of the main metallogenic belts in Northwest China, and described the technical route, main achievements of the project and the future work.