Abstract: In order to meet the urgent need of water supply site selection in North Tibetan Plateau, this study optimized the remote sensing multi-index evaluation model for water supply site selection by meteorology and hydrology, geological environment and landforms in the study area. Also the model complexity and the worklood of remote sensing data extraction were reduced. The study utilized the fuzzy evaluation algorithm for normalizing each factor, and then constructed the multi-index evaluation model for water supply site selection in plateau. Finally, the evaluation index of water supply site selection was calculated by weighted synthesis algorithm. The prediction of the selection evaluation index was consistent with theoretical analysis through the field investigation in the study area. Therefore, the model can work well for water supply site selection in plateau.