Abstract: The review about the Meso-Cenozoic tectonic evolution in Shanxi uplift is an important component for studying the North China Craton evolution and destruction process. The Shanxi area, in the center of North China Craton, is always in the transition zone whenever the lithosphere movement events like differential evolutions, tectonic transition, magmatic activity and physiognomy-reverse happen. This predominant location indicates the important significance of this area in North China Craton study. On the basis of the results of 1∶50 000 and 1∶250 000 geological surveys, the paper studys Mesozoic regional fracture, Cenozoic Fen-Wei rift valley and mountain uplift, analyze the following tectonic evolution processes: Mesozoic lithosphere in Shanxi uplift from thickening to thinning, the tectonic transition from compression to extension, and geomorphic pattern from “east-high, west-low” to “west-high, east-low”, and conclude that Meso-Cenozoic tectonic systems evolution is subjected to the uniform regional dynamic setting. The deep asthenosphere transformation is caused by the interaction between surrounding blocks. As asthenosphere sinks, lithosphere would become relatively thickening, and crust would extend in vertical and shrink in transverse. While asthenosphere upwells, lithosphere would become relatively thinning, and crust would extend in horizontal. Meso-Cenozoic tectonic deformation, sedimentary pattern and magmatic activity are controlled by asthenosphere transformation.