Abstract: The main achievements and knowledge of mineral resource potential evaluation in Central-southern China are got by the project named ‘Technical requirements of national mineral resource potential evaluation’. In this paper, the authors analyzed metallogenic geological background, geophysics, geochemistry, remote sensing, natural heavy fraction, metallogenic regularity, mineral resource prediction, metallogenesis and prospecting direction for 20 important minerals in Central- southern China. On the basis of metallogenic geological background analyses of the important mineral deposits and tectonic unit division, some new evidences and cognitions about boundary of Yangtze landmass and Wuyi-Yunkai orogenic belt are proposed. The comprehensive anomaly of the various kinds of geophysical, geochemical, remote sensing and natural heavy fraction, a serial of maps, and various kinds of data bases were determined through summarizing different tectofacies, metallogenesis in different eras, and spatial-temporal distribution characters of the important mineral deposits in this area. The important mineral resources potentials are quantitatively evaluated and mineral prospective areas are delineated. Besides the prospecting directions are indicated. These achievements will provide reliable foundation for the regional metallogenic regularities and promote the mineral exploration in Central-southern China.